Chimeric antigen receptor T-cells for glioblastoma: The journey ahead

Chimeric antigen receptor T-cells for glioblastoma: The journey ahead

Chimeric antigen receptors (CARs) are genetically engineered transmembrane cell receptors consisting of an antigen-binding ectodomain fused to an activating intracellular T-cell signaling chain. Grafting CAR molecules on T-cells enables targeted killing of tumors. The gene therapy approach of modify...

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Bibliographic Details
Main Authors: Sujith Kurian Joseph, Nabil M Ahmed, Meenakshi Hegde
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Glioma
Subjects:
Chemokine
chimeric antigen receptor T-cells
chimeric antigen receptors
clinical trials
glioblastoma
immune cells
immunotherapy
microenvironment
Online Access:http://www.jglioma.com/article.asp?issn=2589-6113;year=2019;volume=2;issue=2;spage=88;epage=95;aulast=Joseph

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http://www.jglioma.com/article.asp?issn=2589-6113;year=2019;volume=2;issue=2;spage=88;epage=95;aulast=Joseph

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