Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice

Site-1 protease (S1P) is a proprotein convertase with essential functions in the conversion of precursor proteins to their active form. In earlier studies, we demonstrated that S1P ablation in the chondrocyte lineage results in a drastic reduction in endochondral bone formation. To investigate the m...

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Bibliographic Details
Main Authors: Debabrata Patra, Elizabeth DeLassus, Jennifer Mueller, Grazia Abou-Ezzi, Linda J. Sandell
Format: Article
Language:English
Published: The Company of Biologists 2018-02-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/7/2/bio032094