The Role of the Cyclin Dependent Kinase Inhibitor p21<sup>cip1/waf1</sup> in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics
p21<b><sup>cip1/waf1</sup></b> mediates various biological activities by sensing and responding to multiple stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor suppressor mainly by inhibiting cell cycle progression and allowing DNA repair. Sign...
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MDPI AG
2019-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/10/1475 |
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doaj-79e7d812a1174eaeb95129a5f7b35b262020-11-24T22:08:19ZengMDPI AGCancers2072-66942019-09-011110147510.3390/cancers11101475cancers11101475The Role of the Cyclin Dependent Kinase Inhibitor p21<sup>cip1/waf1</sup> in Targeting Cancer: Molecular Mechanisms and Novel TherapeuticsSamar Al Bitar0Hala Gali-Muhtasib1Department of Biology, and Center for Drug Discovery, American University of Beirut, Beirut 1103, LebanonDepartment of Biology, and Center for Drug Discovery, American University of Beirut, Beirut 1103, Lebanonp21<b><sup>cip1/waf1</sup></b> mediates various biological activities by sensing and responding to multiple stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor suppressor mainly by inhibiting cell cycle progression and allowing DNA repair. Significant advances have been made in elucidating the potential role of p21 in promoting tumorigenesis. Here, we discuss the involvement of p21 in multiple signaling pathways, its dual role in cancer, and the importance of understanding its paradoxical functions for effectively designing therapeutic strategies that could selectively inhibit its oncogenic activities, override resistance to therapy and yet preserve its tumor suppressive functions.https://www.mdpi.com/2072-6694/11/10/1475p21signaling pathwayscell cycledual rolecancer therapychemoresistance |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Samar Al Bitar Hala Gali-Muhtasib |
| spellingShingle |
Samar Al Bitar Hala Gali-Muhtasib The Role of the Cyclin Dependent Kinase Inhibitor p21<sup>cip1/waf1</sup> in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics Cancers p21 signaling pathways cell cycle dual role cancer therapy chemoresistance |
| author_facet |
Samar Al Bitar Hala Gali-Muhtasib |
| author_sort |
Samar Al Bitar |
| title |
The Role of the Cyclin Dependent Kinase Inhibitor p21<sup>cip1/waf1</sup> in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics |
| title_short |
The Role of the Cyclin Dependent Kinase Inhibitor p21<sup>cip1/waf1</sup> in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics |
| title_full |
The Role of the Cyclin Dependent Kinase Inhibitor p21<sup>cip1/waf1</sup> in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics |
| title_fullStr |
The Role of the Cyclin Dependent Kinase Inhibitor p21<sup>cip1/waf1</sup> in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics |
| title_full_unstemmed |
The Role of the Cyclin Dependent Kinase Inhibitor p21<sup>cip1/waf1</sup> in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics |
| title_sort |
role of the cyclin dependent kinase inhibitor p21<sup>cip1/waf1</sup> in targeting cancer: molecular mechanisms and novel therapeutics |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2019-09-01 |
| description |
p21<b><sup>cip1/waf1</sup></b> mediates various biological activities by sensing and responding to multiple stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor suppressor mainly by inhibiting cell cycle progression and allowing DNA repair. Significant advances have been made in elucidating the potential role of p21 in promoting tumorigenesis. Here, we discuss the involvement of p21 in multiple signaling pathways, its dual role in cancer, and the importance of understanding its paradoxical functions for effectively designing therapeutic strategies that could selectively inhibit its oncogenic activities, override resistance to therapy and yet preserve its tumor suppressive functions. |
| topic |
p21 signaling pathways cell cycle dual role cancer therapy chemoresistance |
| url |
https://www.mdpi.com/2072-6694/11/10/1475 |
| work_keys_str_mv |
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| _version_ |
1725816624005513216 |