Oncolytic Immunotherapy: Conceptual Evolution, Current Strategies, and Future Perspectives

Oncolytic Immunotherapy: Conceptual Evolution, Current Strategies, and Future Perspectives

The concept of oncolytic virus (OV)-mediated cancer therapy has been shifted from an operational virotherapy paradigm to an immunotherapy. OVs often induce immunogenic cell death (ICD) of cancer cells, and they may interact directly with immune cells as well to prime antitumor immunity. We and other...

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Bibliographic Details
Main Authors: Zong Sheng Guo, Zuqiang Liu, Stacy Kowalsky, Mathilde Feist, Pawel Kalinski, Binfeng Lu, Walter J. Storkus, David L. Bartlett
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
immunogenic cell death
ICD inducer
antigen
cross-presentation
immune checkpoint blockade
antitumor immunity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00555/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00555/full

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