Effects of the Antimicrobial Peptide LL-37 and Innate Effector Mechanisms in Colistin-Resistant Klebsiella pneumoniae With mgrB Insertions

Effects of the Antimicrobial Peptide LL-37 and Innate Effector Mechanisms in Colistin-Resistant Klebsiella pneumoniae With mgrB Insertions

BackgroundColistin is a polypeptide antibiotic drug that targets lipopolysaccharides in the outer membrane of Gram-negative bacteria. Inactivation of the mgrB-gene is a common mechanism behind colistin-resistance in Klebsiella pneumoniae (Kpn). Since colistin is a cyclic polypeptide, it may exhibit...

Full description

Bibliographic Details
Main Authors: Hissa M. Al-Farsi, Salma Al-Adwani, Sultan Ahmed, Carmen Vogt, Anoop T. Ambikan, Anna Leber, Amina Al-Jardani, Saleh Al-Azri, Zakariya Al-Muharmi, Muhammet S. Toprak, Christian G. Giske, Peter Bergman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Microbiology
Subjects:
cross-resistance
colistin
LL-37
innate immunity
zeta potential
whole blood killing assay
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02632/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.02632/full

Similar Items