Posttranscriptional regulation of SOD1 gene expression under oxidative stress: Potential role of ELAV proteins in sporadic ALS

Posttranscriptional regulation of SOD1 gene expression under oxidative stress: Potential role of ELAV proteins in sporadic ALS

Increased levels of SOD1 mRNA have been observed in sporadic ALS patients (SALS) compared to controls. Hence, the understanding of the mechanisms by which SOD1 gene expression is modulated may shed new light on SOD1 involvement in ALS. Of interest, some adenine/uracil-rich elements (AREs) in SOD1 3′...

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Bibliographic Details
Main Authors: Pamela Milani, Marialaura Amadio, Umberto Laforenza, Michela Dell'Orco, Luca Diamanti, Valentina Sardone, Stella Gagliardi, Stefano Govoni, Mauro Ceroni, Alessia Pascale, Cristina Cereda
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Neurobiology of Disease
Subjects:
Sporadic amyotrophic lateral sclerosis
SOD1
mRNA
Posttranscriptional regulation
ELAV proteins
Peripheral blood mononuclear cells
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611300226X

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http://www.sciencedirect.com/science/article/pii/S096999611300226X

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