HPV16-E7-Specific Activated CD8 T Cells in E7 Transgenic Skin and Skin Grafts

HPV16-E7-Specific Activated CD8 T Cells in E7 Transgenic Skin and Skin Grafts

Human papillomavirus (HPV) 16 E7 (E7) protein expression in skin promotes epithelial hyperproliferation and transformation to malignancy. Grafts of murine skin expressing E7 protein as a transgene in keratinocytes are not rejected from immunocompetent recipients, whereas grafts expressing ovalbumin...

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Bibliographic Details
Main Authors: Seyed Davoud Jazayeri, Paula T. Kuo, Graham Robert Leggatt, Ian H. Frazer
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
human papillomavirus
skin grafting
E7-specific CD8+ T cells
T cell migration
immunotherapy
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00524/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00524/full

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