Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes.

Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes.

Although the induction of cytochrome P450 (CYP) has long been investigated in patients with cirrhosis, the question whether liver dysfunction impairs the response to CYP inducers still remains unresolved. Moreover, the mechanism underlying the possible effect of cirrhosis on induction has not been i...

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Bibliographic Details
Main Authors: Maura Floreani, Sara De Martin, Daniela Gabbia, Massimo Barbierato, Alberto Nassi, Claudia Mescoli, Rocco Orlando, Sergio Bova, Paolo Angeli, Elisabetta Gola, Antonietta Sticca, Pietro Palatini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3633963?pdf=render

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http://europepmc.org/articles/PMC3633963?pdf=render

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