Synthesis and Evaluation of Novel Iminosugars Prepared from Natural Amino Acids

Synthesis and Evaluation of Novel Iminosugars Prepared from Natural Amino Acids

Cyclopropanated iminosugars have a locked conformation that may enhance the inhibitory activity and selectivity against different glycosidases. We show the synthesis of new cyclopropane-containing piperidines bearing five stereogenic centers from natural amino acids <span style="font-variant...

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Bibliographic Details
Main Authors: Alejandro Puet, Gema Domínguez, Francisco Javier Cañada, Javier Pérez-Castells
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
piperidine iminosugars
glycosidase inhibition
metathesis
sulfur ylide cyclopropanation
Online Access:https://www.mdpi.com/1420-3049/26/2/394

Internet

https://www.mdpi.com/1420-3049/26/2/394

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