Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression

Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression

The reduced expression of solute carrier family 2, facilitated glucose transporter member 4 (GLUT4) and hexokinase-2 (HK2) in skeletal muscle participates in insulin resistance of diabetes mellitus (DM). MicroRNAs (miRNAs) have emerged as important modulators of mRNA/protein expression, but their ro...

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Bibliographic Details
Main Authors: João V. Esteves, Caio Y. Yonamine, Danilo C. Pinto-Junior, Frederico Gerlinger-Romero, Francisco J. Enguita, Ubiratan F. Machado
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Endocrinology
Subjects:
microRNA
skeletal muscle
GLUT4
hexokinase
glucose metabolism
glucose uptake
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00536/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00536/full

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