Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

TDP-43 is the major component protein of ubiquitin-positive inclusions in brains of patients with frontotemporal lobar degeneration (FTLD-TDP) or amyotrophic lateral sclerosis (ALS). Here, we report the characterization of prion-like properties of aggregated TDP-43 prepared from diseased brains. Wh...

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Bibliographic Details
Main Authors: Takashi Nonaka, Masami Masuda-Suzukake, Tetsuaki Arai, Yoko Hasegawa, Hiroyasu Akatsu, Tomokazu Obi, Mari Yoshida, Shigeo Murayama, David M.A. Mann, Haruhiko Akiyama, Masato Hasegawa
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713002854

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http://www.sciencedirect.com/science/article/pii/S2211124713002854

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