Imprinting of Mesenchymal Stromal Cell Transcriptome Persists even after Treatment in Patients with Multiple Myeloma

Imprinting of Mesenchymal Stromal Cell Transcriptome Persists even after Treatment in Patients with Multiple Myeloma

Introduction. Multiple myeloma (MM) is a B-cell neoplasm characterized by clonal expansion of malignant plasma cells (MM cells) in the bone-marrow (BM) compartment. BM mesenchymal stromal cells (MSC) from newly diagnosed MM patients were shown to be involved in MM pathogenesis and chemoresistance. T...

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Bibliographic Details
Main Authors: Léa Lemaitre, Laura DoSouto Ferreira, Marie-Véronique Joubert, Hervé Avet-Loiseau, Ludovic Martinet, Jill Corre, Bettina Couderc
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
multiple myeloma
mesenchymal stromal cells
transcriptome
imprinting
adipogenesis
immunogenicity
Online Access:https://www.mdpi.com/1422-0067/21/11/3854

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https://www.mdpi.com/1422-0067/21/11/3854

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