Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats

Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats

Abstract Background The proinflammatory cytokine interleukin-1β (IL-1β) drives pain by inducing the expression of inflammatory mediators; however, its ability to regulate sodium channel 1.7 (Nav1.7), a key driver of temporomandibular joint (TMJ) hypernociception, remains unknown. IL-1β induces cyclo...

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Bibliographic Details
Main Authors: Peng Zhang, Rui-Yun Bi, Ye-Hua Gan
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Neuroinflammation
Subjects:
IL-1β
Nav1.7
Trigeminal ganglion
Satellite glial cells
Neuron
TMJ
Online Access:http://link.springer.com/article/10.1186/s12974-018-1154-0

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http://link.springer.com/article/10.1186/s12974-018-1154-0

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