PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients.

PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients.

The expression of checkpoint blockade molecules PD-1, PD-L1, CTLA-4, and foxp3+CD25+CD4+ T cells (Tregs) regulate donor T cell activation and graft-vs-host disease (GvHD) in allogeneic hematopoietic stem cell transplant (allo-HSCT). Detailed kinetics of PD-1-, CTLA-4-, and PD-L1 expression on donor...

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Bibliographic Details
Main Authors: Mohammad S Hossain, Ghada M Kunter, Vicky F El-Najjar, David L Jaye, Zaid Al-Kadhimi, Owonikoko K Taofeek, Jian-Ming Li, Edmund K Waller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5617147?pdf=render

Internet

http://europepmc.org/articles/PMC5617147?pdf=render

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