The Rho-associated kinase inhibitor fasudil can replace Y-27632 for use in human pluripotent stem cell research.

The Rho-associated kinase inhibitor fasudil can replace Y-27632 for use in human pluripotent stem cell research.

Poor survival of human pluripotent stem cells (hPSCs) following freezing, thawing, or passaging hinders the maintenance and differentiation of stem cells. Rho-associated kinases (ROCKs) play a crucial role in hPSC survival. To date, a typical ROCK inhibitor, Y-27632, has been the primary agent used...

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Bibliographic Details
Main Authors: Seongjun So, Yeonmi Lee, Jiwan Choi, Seoon Kang, Ji-Yoon Lee, Julie Hwang, Joosung Shin, James R Dutton, Eul-Ju Seo, Beom Hee Lee, Chong Jai Kim, Shoukhrat Mitalipov, Soo Jin Oh, Eunju Kang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0233057

Internet

https://doi.org/10.1371/journal.pone.0233057

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