A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring

A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring

Maternal diabetes is known to adversely influence brain development in offspring. Here, we provide evidence that this involves the circulating metabolite methylglyoxal, which is increased in diabetes, and its detoxifying enzyme, glyoxalase 1 (Glo1), which when mutated is associated with neurodevelop...

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Bibliographic Details
Main Authors: Guang Yang, Gonzalo I. Cancino, Siraj K. Zahr, Axel Guskjolen, Anastassia Voronova, Denis Gallagher, Paul W. Frankland, David R. Kaplan, Freda D. Miller
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
neural stem cells
neurogenesis
cortical development
Glyoxalase 1
methylglyoxal
neurodevelopmental disorders
maternal diabetes
autism spectrum disorder
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716313237

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http://www.sciencedirect.com/science/article/pii/S2211124716313237

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