Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease

Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease

Huntington's disease (HD) is caused by a highly polymorphic CAG trinucleotide expansion in the gene encoding for the huntingtin protein (HTT). The resulting mutant huntingtin protein (mutHTT) is ubiquitously expressed but also exhibits the ability to propagate from cell-to-cell to disseminate p...

Full description

Bibliographic Details
Main Authors: Stefan Bartl, Abid Oueslati, Amber L. Southwell, Alberto Siddu, Michela Parth, Linda Suzanne David, Alexander Maxan, Nina Salhat, Markus Burkert, Andreas Mairhofer, Theresa Friedrich, Halyna Pankevych, Katja Balazs, Guenther Staffler, Michael R. Hayden, Francesca Cicchetti, Oskar W. Smrzka
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Therapeutic antibody
Extracellular mutHTT
Cell-to-cell propagation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120302187

Internet

http://www.sciencedirect.com/science/article/pii/S0969996120302187

Similar Items