The Gq signalling pathway inhibits brown and beige adipose tissue
Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice and in human adipocytes.
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Nature Publishing Group
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10895 |
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doaj-7a2bc9f5eaee4df68bf0b1b7a219eba32021-05-11T10:50:58ZengNature Publishing GroupNature Communications2041-17232016-03-017111010.1038/ncomms10895The Gq signalling pathway inhibits brown and beige adipose tissueKatarina Klepac0Ana Kilić1Thorsten Gnad2Loren M. Brown3Beate Herrmann4Andrea Wilderman5Aileen Balkow6Anja Glöde7Katharina Simon8Martin E. Lidell9Matthias J. Betz10Sven Enerbäck11Jürgen Wess12Marc Freichel13Matthias Blüher14Gabi König15Evi Kostenis16Paul A. Insel17Alexander Pfeifer18Institute of Pharmacology and Toxicology, University Hospital Bonn, University of BonnInstitute of Pharmacology and Toxicology, University Hospital Bonn, University of BonnInstitute of Pharmacology and Toxicology, University Hospital Bonn, University of BonnInstitute of Pharmacology and Toxicology, University Hospital Bonn, University of BonnInstitute of Pharmacology and Toxicology, University Hospital Bonn, University of BonnDepartment of Pharmacology, University of CaliforniaInstitute of Pharmacology and Toxicology, University Hospital Bonn, University of BonnInstitute of Pharmacology and Toxicology, University Hospital Bonn, University of BonnResearch Training Group 1873, University of BonnDepartment of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of GothenburgDepartment of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of GothenburgDepartment of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of GothenburgMolecular Signalling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesInstitute of Pharmacology, University of HeidelbergDepartment of Medicine, University of LeipzigInstitute of Pharmaceutical Biology, University of BonnResearch Training Group 1873, University of BonnDepartment of Pharmacology, University of CaliforniaInstitute of Pharmacology and Toxicology, University Hospital Bonn, University of BonnBrown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice and in human adipocytes.https://doi.org/10.1038/ncomms10895 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Katarina Klepac Ana Kilić Thorsten Gnad Loren M. Brown Beate Herrmann Andrea Wilderman Aileen Balkow Anja Glöde Katharina Simon Martin E. Lidell Matthias J. Betz Sven Enerbäck Jürgen Wess Marc Freichel Matthias Blüher Gabi König Evi Kostenis Paul A. Insel Alexander Pfeifer |
| spellingShingle |
Katarina Klepac Ana Kilić Thorsten Gnad Loren M. Brown Beate Herrmann Andrea Wilderman Aileen Balkow Anja Glöde Katharina Simon Martin E. Lidell Matthias J. Betz Sven Enerbäck Jürgen Wess Marc Freichel Matthias Blüher Gabi König Evi Kostenis Paul A. Insel Alexander Pfeifer The Gq signalling pathway inhibits brown and beige adipose tissue Nature Communications |
| author_facet |
Katarina Klepac Ana Kilić Thorsten Gnad Loren M. Brown Beate Herrmann Andrea Wilderman Aileen Balkow Anja Glöde Katharina Simon Martin E. Lidell Matthias J. Betz Sven Enerbäck Jürgen Wess Marc Freichel Matthias Blüher Gabi König Evi Kostenis Paul A. Insel Alexander Pfeifer |
| author_sort |
Katarina Klepac |
| title |
The Gq signalling pathway inhibits brown and beige adipose tissue |
| title_short |
The Gq signalling pathway inhibits brown and beige adipose tissue |
| title_full |
The Gq signalling pathway inhibits brown and beige adipose tissue |
| title_fullStr |
The Gq signalling pathway inhibits brown and beige adipose tissue |
| title_full_unstemmed |
The Gq signalling pathway inhibits brown and beige adipose tissue |
| title_sort |
gq signalling pathway inhibits brown and beige adipose tissue |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-03-01 |
| description |
Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice and in human adipocytes. |
| url |
https://doi.org/10.1038/ncomms10895 |
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