Designer GPCRs as Novel Tools to Identify Metabolically Important Signaling Pathways

by Jürgen Wess
Published 2021-07-01

Ultrasonic vocalizations induced by sex and amphetamine in M2, M4, M5 muscarinic and D2 dopamine receptor knockout mice.

by Haoran Wang, Shuyin Liang, Jeffrey Burgdorf, Jurgen Wess, John Yeomans
Published 2008-01-01

Adipocyte Gi signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity

by Lei Wang, Sai P. Pydi, Lu Zhu, Luiz F. Barella, Yinghong Cui, Oksana Gavrilova, Kendra K. Bence, Cecile Vernochet, Jürgen Wess
Published 2020-06-01

β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity

by Luiz F. Barella, Mario Rossi, Sai P. Pydi, Jaroslawna Meister, Shanu Jain, Yinghong Cui, Oksana Gavrilova, Gianluca Fulgenzi, Lino Tessarollo, Jürgen Wess
Published 2021-06-01

Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake

by Ken-ichiro Nakajima, Zhenzhong Cui, Chia Li, Jaroslawna Meister, Yinghong Cui, Ou Fu, Adam S. Smith, Shalini Jain, Bradford B. Lowell, Michael J. Krashes, Jürgen Wess
Published 2016-01-01

Correction: Corrigendum: Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake

by Ken-ichiro Nakajima, Zhenzhong Cui, Chia Li, Jaroslawna Meister, Yinghong Cui, Ou Fu, Adam S. Smith, Shalini Jain, Bradford B. Lowell, Michael J. Krashes, Jürgen Wess
Published 2016-03-01

Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice.

by Jaroslawna Meister, Derek B J Bone, Grzegorz Godlewski, Ziyi Liu, Regina J Lee, Sergey A Vishnivetskiy, Vsevolod V Gurevich, Danielle Springer, George Kunos, Jürgen Wess
Published 2019-10-01

Selective activation of Gs signaling in adipocytes causes striking metabolic improvements in mice

by Lei Wang, Sai P. Pydi, Yinghong Cui, Lu Zhu, Jaroslawna Meister, Oksana Gavrilova, Rebecca Berdeaux, Jean-Philippe Fortin, Kendra K. Bence, Cecile Vernochet, Jürgen Wess
Published 2019-09-01

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

by Gianluca Fulgenzi, Zhenyi Hong, Francesco Tomassoni-Ardori, Luiz F. Barella, Jodi Becker, Colleen Barrick, Deborah Swing, Sudhirkumar Yanpallewar, Brad St Croix, Jürgen Wess, Oksana Gavrilova, Lino Tessarollo
Published 2020-04-01

Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency.

by Naohito Kitamura, Runa Araya, Moeko Kudoh, Haruo Kishida, Tetsuya Kimura, Miyuki Murayama, Akihiko Takashima, Yuriko Sakamaki, Tsutomu Hashikawa, Shingo Ito, Sumio Ohtsuki, Tetsuya Terasaki, Jürgen Wess, Masahisa Yamada
Published 2009-01-01

The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection.

by Matthew Darby, Corinna Schnoeller, Alykhan Vira, Fiona Jane Culley, Saeeda Bobat, Erin Logan, Frank Kirstein, Jürgen Wess, Adam F Cunningham, Frank Brombacher, Murray E Selkirk, William G C Horsnell
Published 2015-01-01

Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity

by Anna M. Klawonn, Anna M. Klawonn, Daniel B. Wilhelms, Daniel B. Wilhelms, Sarah H. Lindström, Anand Kumar Singh, Anand Kumar Singh, Maarit Jaarola, Jürgen Wess, Michael Fritz, Michael Fritz, David Engblom
Published 2018-04-01

Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice

by Runa Araya, Takanori Noguchi, Munehiro Yuhki, Naohito Kitamura, Makoto Higuchi, Takaomi C. Saido, Kenjiro Seki, Shigeyoshi Itohara, Masako Kawano, Kentaro Tanemura, Akihiko Takashima, Kazuyuki Yamada, Yasushi Kondoh, Iwao Kanno, Jürgen Wess, Masahisa Yamada
Published 2006-11-01

Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis

by Sai P. Pydi, Shanu Jain, Wesley Tung, Yinghong Cui, Lu Zhu, Wataru Sakamoto, Shalini Jain, Brent S. Abel, Monica C. Skarulis, Jie Liu, Thanh Huynh, Karel Pacak, Marc G. Caron, Oksana Gavrilova, Toren Finkel, Jürgen Wess
Published 2019-07-01

The Gq signalling pathway inhibits brown and beige adipose tissue

by Katarina Klepac, Ana Kilić, Thorsten Gnad, Loren M. Brown, Beate Herrmann, Andrea Wilderman, Aileen Balkow, Anja Glöde, Katharina Simon, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Wess, Marc Freichel, Matthias Blüher, Gabi König, Evi Kostenis, Paul A. Insel, Alexander Pfeifer
Published 2016-03-01

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

by Feng Mei, Klaus Lehmann-Horn, Yun-An A Shen, Kelsey A Rankin, Karin J Stebbins, Daniel S Lorrain, Kara Pekarek, Sharon A Sagan, Lan Xiao, Cory Teuscher, H-Christian von Büdingen, Jürgen Wess, J Josh Lawrence, Ari J Green, Stephen PJ Fancy, Scott S Zamvil, Jonah R Chan
Published 2016-09-01

Lack of beta-arrestin signaling in the absence of active G proteins

by Manuel Grundmann, Nicole Merten, Davide Malfacini, Asuka Inoue, Philip Preis, Katharina Simon, Nelly Rüttiger, Nicole Ziegler, Tobias Benkel, Nina Katharina Schmitt, Satoru Ishida, Ines Müller, Raphael Reher, Kouki Kawakami, Ayumi Inoue, Ulrike Rick, Toni Kühl, Diana Imhof, Junken Aoki, Gabriele M. König, Carsten Hoffmann, Jesus Gomeza, Jürgen Wess, Evi Kostenis
Published 2018-01-01

β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

by Lu Zhu, Joana Almaça, Prasanna K. Dadi, Hao Hong, Wataru Sakamoto, Mario Rossi, Regina J. Lee, Nicholas C. Vierra, Huiyan Lu, Yinghong Cui, Sara M. McMillin, Nicole A. Perry, Vsevolod V. Gurevich, Amy Lee, Bryan Kuo, Richard D. Leapman, Franz M. Matschinsky, Nicolai M. Doliba, Nikhil M. Urs, Marc G. Caron, David A. Jacobson, Alejandro Caicedo, Jürgen Wess
Published 2017-02-01