Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity.

Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity.

The origin of sinoatrial node (SAN) pacemaker activity in the heart is controversial. The leading candidates are diastolic depolarization by "funny" current (If) through HCN4 channels (the "Membrane Clock" hypothesis), depolarization by cardiac Na-Ca exchange (NCX1) in response t...

Full description

Bibliographic Details
Main Authors: Sabine Groenke, Eric D Larson, Sarah Alber, Rui Zhang, Scott T Lamp, Xiaoyan Ren, Haruko Nakano, Maria C Jordan, Hrayr S Karagueuzian, Kenneth P Roos, Atsushi Nakano, Catherine Proenza, Kenneth D Philipson, Joshua I Goldhaber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3836769?pdf=render

Internet

http://europepmc.org/articles/PMC3836769?pdf=render

Similar Items