Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.

Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.

The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which is well known to drive potent Th2 responses,...

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Bibliographic Details
Main Authors: Maria M M Kaisar, Manuel Ritter, Carlos Del Fresno, Hulda S Jónasdóttir, Alwin J van der Ham, Leonard R Pelgrom, Gabriele Schramm, Laura E Layland, David Sancho, Clarissa Prazeres da Costa, Martin Giera, Maria Yazdanbakhsh, Bart Everts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2005504

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https://doi.org/10.1371/journal.pbio.2005504

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