Attenuation of prostaglandin E<sub>2 </sub>elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole

Attenuation of prostaglandin E<sub>2 </sub>elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole

<p>Abstract</p> <p>Background</p> <p>Peripheral administration of lipopolysaccharide (LPS) induces inflammation and increases cerebral prostaglandin E<sub>2 </sub>(PGE<sub>2</sub>) concentration. PGE<sub>2 </sub>is eliminated from bra...

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Bibliographic Details
Main Authors: Akanuma Shin-ichi, Uchida Yasuo, Ohtsuki Sumio, Tachikawa Masanori, Terasaki Tetsuya, Hosoya Ken-ichi
Format: Article
Language:English
Published: BMC 2011-10-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood-brain barrier
lipopolysaccharide
inflammation
multidrug resistance-associated protein
MRP4
Oat3
Oatp1a4
PGE<sub>2</sub>
prostaglandin
transporter
Online Access:http://www.fluidsbarrierscns.com/content/8/1/24

Internet

http://www.fluidsbarrierscns.com/content/8/1/24

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