Identification of the organic anion transporting polypeptides responsible for the hepatic uptake of the major metabolite of epyrifenacil, S‐3100‐CA, in mice

Identification of the organic anion transporting polypeptides responsible for the hepatic uptake of the major metabolite of epyrifenacil, S‐3100‐CA, in mice

Abstract Epyrifenacil is a novel herbicide that acts as an inhibitor of protoporphyrinogen oxidase (PPO) and produces hepatotoxicity in rodents by inhibiting PPO. Our previous research revealed that the causal substance of hepatotoxicity is S‐3100‐CA, a major metabolite of epyrifenacil, and that hum...

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Bibliographic Details
Main Authors: Kengo Sakurai, Tomohiro Kuroda, Jun Abe, Hiroshi Toda, Sachiko Kitamoto
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Pharmacology Research & Perspectives
Subjects:
active hepatic uptake
epyrifenacil
gender difference
herbicide
species difference
OATP
Online Access:https://doi.org/10.1002/prp2.877

Internet

https://doi.org/10.1002/prp2.877

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