In Vivo Silencing of A20 via TLR9-Mediated Targeted SiRNA Delivery Potentiates Antitumor Immune Response.

In Vivo Silencing of A20 via TLR9-Mediated Targeted SiRNA Delivery Potentiates Antitumor Immune Response.

A20 is an ubiquitin-editing enzyme that ensures the transient nature of inflammatory signaling pathways induced by cytokines like TNF-α and IL-1 or pathogens via Toll-like receptor (TLR) pathways. It has been identified as a negative regulator of dendritic cell (DC) maturation and attenuator of thei...

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Bibliographic Details
Main Authors: Floriane C M Braun, Jens van den Brandt, Sören Thomas, Sandra Lange, Juliane Schrank, Claudia Gand, Grzegorz K Przybylski, Katrin Schmoeckel, Barbara M Bröker, Christian A Schmidt, Piotr Grabarczyk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4556692?pdf=render

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http://europepmc.org/articles/PMC4556692?pdf=render

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