Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation

Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation

In this study, we characterized the role of host cell protein tyrosyl-DNA phosphodiesterase 2 (TDP2) activity, also known as VPg unlinkase, in picornavirus infections in a human cell model of infection. TDP2/VPg unlinkase is used by picornaviruses to remove the small polypeptide, VPg (Virus Protein...

Full description

Bibliographic Details
Main Authors: Autumn C. Holmes, Guido Zagnoli-Vieira, Keith W. Caldecott, Bert L. Semler
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Viruses
Subjects:
vpg unlinkase
tdp2 (tyrosyl dna phosphodiesterase 2)
picornavirus
poliovirus
coxsackievirus
rna replication
viral translation
retinal pigment epithelial cells (rpe cells)
polysome analysis
Online Access:https://www.mdpi.com/1999-4915/12/2/166

Internet

https://www.mdpi.com/1999-4915/12/2/166

Similar Items