AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

Therapeutic strategies are needed to protect dopaminergic neurons in Parkinson’s disease (PD) patients. Oxidative stress caused by dopamine may play an important role in PD pathogenesis. Selective autophagy of mitochondria (mitophagy), mainly regulated by PINK1 and PARKIN, plays an important role in...

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Bibliographic Details
Main Authors: Anthea Di Rita, Pasquale D’Acunzo, Luca Simula, Silvia Campello, Flavie Strappazzon, Francesco Cecconi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cell death
oxidative stress
in vitro models
Parkinson’s disease
mitophagy
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00092/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00092/full

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