Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism

Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism

Parkinson's disease (PD) is a neurodegenerative condition caused by age-related death of dopaminergic (DA) neurons in the substantia nigra (SN). Mitochondrial DNA (mtDNA) deletions rise exponentially with age in humans and reach their highest levels approaching 60% in dopaminergic neurons of th...

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Bibliographic Details
Main Authors: Lanying Song, Marissa McMackin, Andy Nguyen, Gino Cortopassi
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
mtDNA deletion
Twinkle mutation
Parkin deficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611630314X

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http://www.sciencedirect.com/science/article/pii/S096999611630314X

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