Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism
Parkinson's disease (PD) is a neurodegenerative condition caused by age-related death of dopaminergic (DA) neurons in the substantia nigra (SN). Mitochondrial DNA (mtDNA) deletions rise exponentially with age in humans and reach their highest levels approaching 60% in dopaminergic neurons of th...
Main Authors: | Lanying Song, Marissa McMackin, Andy Nguyen, Gino Cortopassi |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-04-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S096999611630314X |
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