Molecular dynamics of the immune checkpoint programmed cell death protein I, PD-1: conformational changes of the BC-loop upon binding of the ligand PD-L1 and the monoclonal antibody nivolumab

Molecular dynamics of the immune checkpoint programmed cell death protein I, PD-1: conformational changes of the BC-loop upon binding of the ligand PD-L1 and the monoclonal antibody nivolumab

Abstract Background The immune checkpoint receptor programmed cell death protein I (PD-1) has been identified as a key target in immunotherapy. PD-1 reduces the risk of autoimmunity by inducing apoptosis in antigen-specific T cells upon interaction with programmed cell death protein ligand I (PD-L1)...

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Bibliographic Details
Main Authors: Bernhard Roither, Chris Oostenbrink, Wolfgang Schreiner
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Bioinformatics
Subjects:
PD-1
PD-L1
Nivolumab
Molecular dynamics
BC-loop
Mathematical oncology
Online Access:https://doi.org/10.1186/s12859-020-03904-9

Internet

https://doi.org/10.1186/s12859-020-03904-9

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