Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function
Summary: While diet modulates immunity, its impact on B cell ontogeny remains unclear. Using mixture modeling, a large-scale isocaloric dietary cohort mouse study identified carbohydrate as a major driver of B cell development and function. Increasing dietary carbohydrate increased B cell proportion...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221008038 |
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doaj-7a5e95ba684f4b70858620e02385dd8d |
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jian Tan Duan Ni Jibran Abdul Wali Darren Anthony Cox Gabriela Veronica Pinget Jemma Taitz Claire Immediato Daïen Alistair Senior Mark Norman Read Stephen James Simpson Nicholas Jonathan Cole King Laurence Macia |
| spellingShingle |
Jian Tan Duan Ni Jibran Abdul Wali Darren Anthony Cox Gabriela Veronica Pinget Jemma Taitz Claire Immediato Daïen Alistair Senior Mark Norman Read Stephen James Simpson Nicholas Jonathan Cole King Laurence Macia Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function iScience Biological sciences Immunology Cell biology Developmental biology |
| author_facet |
Jian Tan Duan Ni Jibran Abdul Wali Darren Anthony Cox Gabriela Veronica Pinget Jemma Taitz Claire Immediato Daïen Alistair Senior Mark Norman Read Stephen James Simpson Nicholas Jonathan Cole King Laurence Macia |
| author_sort |
Jian Tan |
| title |
Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function |
| title_short |
Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function |
| title_full |
Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function |
| title_fullStr |
Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function |
| title_full_unstemmed |
Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function |
| title_sort |
dietary carbohydrate, particularly glucose, drives b cell lymphopoiesis and function |
| publisher |
Elsevier |
| series |
iScience |
| issn |
2589-0042 |
| publishDate |
2021-08-01 |
| description |
Summary: While diet modulates immunity, its impact on B cell ontogeny remains unclear. Using mixture modeling, a large-scale isocaloric dietary cohort mouse study identified carbohydrate as a major driver of B cell development and function. Increasing dietary carbohydrate increased B cell proportions in spleen, mesenteric lymph node and Peyer’s patches, and increased antigen-specific immunoglobulin G production after immunization. This was linked to increased B lymphopoiesis in the bone marrow. Glucose promoted early B lymphopoiesis and higher total B lymphocyte numbers than fructose. It drove B cell development through glycolysis and oxidative phosphorylation, independently of fatty acid oxidation in vitro and reduced B cell apoptosis in early development via mTOR activation, independently of interleukin-7. Ours is the first comprehensive study showing the impact of macronutrients on B cell development and function. It shows the quantitative and qualitative interplay between dietary carbohydrate and B cells and argues for dietary modulation in B cell-targeting strategies. |
| topic |
Biological sciences Immunology Cell biology Developmental biology |
| url |
http://www.sciencedirect.com/science/article/pii/S2589004221008038 |
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doaj-7a5e95ba684f4b70858620e02385dd8d2021-08-22T04:30:19ZengElsevieriScience2589-00422021-08-01248102835Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and functionJian Tan0Duan Ni1Jibran Abdul Wali2Darren Anthony Cox3Gabriela Veronica Pinget4Jemma Taitz5Claire Immediato Daïen6Alistair Senior7Mark Norman Read8Stephen James Simpson9Nicholas Jonathan Cole King10Laurence Macia11Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Pathology School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; CHRU Montpellier, Département de Rhumatologie, Montpellier FRANCE & University of Montpellier, PhyMedExp, INSERM, CNRS UMR, Montpellier, FranceCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; School of Computer Science, Faculty of Engineering, University of Sydney, Sydney, NSW, Australia; School of Mathematics and Statistics, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; School of Computer Science, Faculty of Engineering, University of Sydney, Sydney, NSW, Australia; The Westmead Initiative, Faculty of Engineering, The University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, AustraliaCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Pathology School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; Sydney Cytometry, The University of Sydney and The Centenary Institute, Sydney, NSW, Australia; Corresponding authorCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; Corresponding authorSummary: While diet modulates immunity, its impact on B cell ontogeny remains unclear. Using mixture modeling, a large-scale isocaloric dietary cohort mouse study identified carbohydrate as a major driver of B cell development and function. Increasing dietary carbohydrate increased B cell proportions in spleen, mesenteric lymph node and Peyer’s patches, and increased antigen-specific immunoglobulin G production after immunization. This was linked to increased B lymphopoiesis in the bone marrow. Glucose promoted early B lymphopoiesis and higher total B lymphocyte numbers than fructose. It drove B cell development through glycolysis and oxidative phosphorylation, independently of fatty acid oxidation in vitro and reduced B cell apoptosis in early development via mTOR activation, independently of interleukin-7. Ours is the first comprehensive study showing the impact of macronutrients on B cell development and function. It shows the quantitative and qualitative interplay between dietary carbohydrate and B cells and argues for dietary modulation in B cell-targeting strategies.http://www.sciencedirect.com/science/article/pii/S2589004221008038Biological sciencesImmunologyCell biologyDevelopmental biology |