Exosomal LncRNA–NEAT1 derived from MIF-treated mesenchymal stem cells protected against doxorubicin-induced cardiac senescence through sponging miR-221-3p

Exosomal LncRNA–NEAT1 derived from MIF-treated mesenchymal stem cells protected against doxorubicin-induced cardiac senescence through sponging miR-221-3p

Abstract Background The chemotherapy drug doxorubicin (Dox) is widely used for treating a variety of cancers. However, its high cardiotoxicity hampered its clinical use. Exosomes derived from stem cells showed a therapeutic effect against Dox-induced cardiomyopathy (DIC). Previous studies reported t...

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Bibliographic Details
Main Authors: Lei Zhuang, Wenzheng Xia, Didi Chen, Yijia Ye, Tingting Hu, Shiting Li, Meng Hou
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Nanobiotechnology
Subjects:
Mesenchymal stem cells
Exosome
Macrophage migration inhibitory factor (MIF)
Doxorubicin-induced cardiomyopathy
LncRNA-NEAT1/miR-221-3p/Sirt2 signaling pathway
Online Access:http://link.springer.com/article/10.1186/s12951-020-00716-0

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http://link.springer.com/article/10.1186/s12951-020-00716-0

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