Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans

Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans

Abstract Pathologically altered tau protein is a common denominator of neurodegenerative disorders including Alzheimer’s disease (AD) and other tauopathies. Therefore, promising immunotherapeutic approaches target and eliminate extracellular pathogenic tau species, which are thought to be responsibl...

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Bibliographic Details
Main Authors: Petronela Weisová, Ondrej Cehlár, Rostislav Škrabana, Monika Žilková, Peter Filipčík, Branislav Kováčech, Michal Prčina, Ľubica Wojčiaková, Ľubica Fialová, Tomáš Smolek, Eva Kontseková, Norbert Žilka, Michal Novák
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Tau
Immunotherapy
Mechanism of action
Spreading
Heparan sulfate
Online Access:http://link.springer.com/article/10.1186/s40478-019-0770-y

Internet

http://link.springer.com/article/10.1186/s40478-019-0770-y

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