Regulation of Mitochondria-Associated Membranes (MAMs) by NO/sGC/PKG Participates in the Control of Hepatic Insulin Response

Regulation of Mitochondria-Associated Membranes (MAMs) by NO/sGC/PKG Participates in the Control of Hepatic Insulin Response

Under physiological conditions, nitric oxide (NO) produced by the endothelial NO synthase (eNOS) upregulates hepatic insulin sensitivity. Recently, contact sites between the endoplasmic reticulum and mitochondria named mitochondria-associated membranes (MAMs) emerged as a crucial hub for insulin sig...

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Bibliographic Details
Main Authors: Arthur Bassot, Marie-Agnès Chauvin, Nadia Bendridi, Jingwei Ji-Cao, Guillaume Vial, Léa Monnier, Birke Bartosch, Anaïs Alves, Cécile Cottet-Rousselle, Yves Gouriou, Jennifer Rieusset, Béatrice Morio
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
mitochondria-associated endoplasmic reticulum membranes
nitric oxide
cyclic guanosine monophosphate (cgmp)-dependent protein kinase
hepatic glucose metabolism
metabolic flexibility
Online Access:https://www.mdpi.com/2073-4409/8/11/1319

Internet

https://www.mdpi.com/2073-4409/8/11/1319

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