Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate

Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate

Abstract Currently, there are no commercially available live‐attenuated vaccines against chikungunya virus (CHIKV). Here, CHIKVs with mutations in non‐structural proteins (nsPs) were investigated for their suitability as attenuated CHIKV vaccines. R532H mutation in nsP1 caused reduced infectivity in...

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Bibliographic Details
Main Authors: Yi‐Hao Chan, Teck‐Hui Teo, Age Utt, Jeslin JL Tan, Siti Naqiah Amrun, Farhana Abu Bakar, Wearn‐Xin Yee, Etienne Becht, Cheryl Yi‐Pin Lee, Bernett Lee, Ravisankar Rajarethinam, Evan Newell, Andres Merits, Guillaume Carissimo, Fok‐Moon Lum, Lisa FP Ng
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:EMBO Molecular Medicine
Subjects:
chikungunya
live‐attenuated vaccine
mutation
neutralizing antibody
non‐structural protein
Online Access:https://doi.org/10.15252/emmm.201810092

Internet

https://doi.org/10.15252/emmm.201810092

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