Assessment of copy number variation in genes related to drug resistance in Plasmodium vivax and Plasmodium falciparum isolates from the Brazilian Amazon and a systematic review of the literature

Assessment of copy number variation in genes related to drug resistance in Plasmodium vivax and Plasmodium falciparum isolates from the Brazilian Amazon and a systematic review of the literature

Abstract Background Parasite resistance to anti-malarials represents a great obstacle for malaria elimination. The majority of studies have investigated the association between single-nucleotide polymorphisms (SNPs) and drug resistance; however, it is becoming clear that the copy number variation (C...

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Bibliographic Details
Main Authors: Gabriel Luíz Costa, Lara Cotta Amaral, Cor Jesus Fernandes Fontes, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito, Taís Nóbrega de Sousa
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum
Plasmodium vivax
Drug resistance
Copy number variation
Single nucleotide polymorphism
Online Access:http://link.springer.com/article/10.1186/s12936-017-1806-z

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http://link.springer.com/article/10.1186/s12936-017-1806-z

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