Identification of cGAS as an innate immune sensor of extracellular bacterium Pseudomonas aeruginosa

Identification of cGAS as an innate immune sensor of extracellular bacterium Pseudomonas aeruginosa

Summary: Cyclic GMP-AMP synthase (cGAS) is reported essential for detecting intracellular bacteria. However, it remains to be determined whether and how cGAS is involved in extracellular bacterial infection. Here, we report that cGAS is essential for mediating type I interferon (IFN) production in i...

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Bibliographic Details
Main Authors: Chuan-min Zhou, Biao Wang, Qun Wu, Ping Lin, Shu-gang Qin, Qin-qin Pu, Xue-jie Yu, Min Wu
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Immune Response
Microbiology
Bacteriology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220311251

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220311251

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