Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells

Ribosome biogenesis is a highly complex process requiring many assisting factors. Studies in yeast have yielded comprehensive knowledge of the cellular machinery involved in this process. However, many aspects of ribosome synthesis are different in higher eukaryotes, and the global set of mammalian...

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Bibliographic Details
Main Authors: Lukas Badertscher, Thomas Wild, Christian Montellese, Leila T. Alexander, Lukas Bammert, Marie Sarazova, Michael Stebler, Gabor Csucs, Thomas U. Mayer, Nicola Zamboni, Ivo Zemp, Peter Horvath, Ulrike Kutay
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Subjects:
ribosome synthesis
RNAi screening
cullin E3 ubiquitin ligase
glutamine metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715014102

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http://www.sciencedirect.com/science/article/pii/S2211124715014102

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