Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm

Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm

Objective(s): Calcineurin (CN) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. The FK-506 (tacrolimus),a phosphatase inhibitor, is a fungal-derived agent and a common immune suppressant extensively used for tissue transplantation. To further...

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Bibliographic Details
Main Authors: Amirmasoud Hadjiasgary, Hamid Reza Banafshe, Abolfazl Ardjmand
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2015-02-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Avoidance learning Calcineurin FK-506 Learning Memory Phosphatase inhibitor Rat Tacrimolus
Online Access:http://ijbms.mums.ac.ir/pdf_4013_f69a4b16a40fabe26944f73b37e75fba.html

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http://ijbms.mums.ac.ir/pdf_4013_f69a4b16a40fabe26944f73b37e75fba.html

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