p53‐independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells

p53‐independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells

The platinum‐based DNA damaging agent cisplatin is used as a standard therapy for locally advanced head and neck squamous cell carcinoma (HNSCC). However, the mechanisms underpinning the cytotoxic effects of this compound are not entirely elucidated. Cisplatin produces anticancer effects primarily v...

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Bibliographic Details
Main Authors: Kanika Sharma, Thien‐Trang Vu, Wade Cook, Mitra Naseri, Kevin Zhan, Wataru Nakajima, Hisashi Harada
Format: Article
Language:English
Published: Wiley 2018-06-01
Series:Molecular Oncology
Subjects:
apoptosis
ATF
cisplatin
ERK1
Noxa
Online Access:https://doi.org/10.1002/1878-0261.12172

Internet

https://doi.org/10.1002/1878-0261.12172

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