Synthesis and antimicrobial activity of 1H-1,2,3-triazole and carboxylate analogues of metronidazole

Synthesis and antimicrobial activity of 1H-1,2,3-triazole and carboxylate analogues of metronidazole

Herein, a series of novel 1H-1,2,3-triazole and carboxylate derivatives of metronidazole (5a–i and 7a–e) were synthesized and evaluated for their antimicrobial activity in vitro. All the newly synthesized compounds were characterized by 1H NMR, 13C NMR, HRMS, and 19F NMR (5b, 5c and 5h) spectroscopy...

Full description

Bibliographic Details
Main Authors: Satya Kumar Avula, Syed Raza Shah, Khdija Al-Hosni, Muhammad U. Anwar, Rene Csuk, Biswanath Das, Ahmed Al-Harrasi
Format: Article
Language:English
Published: Beilstein-Institut 2021-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
antimicrobial agents
carboxylate analogues
1h-1,2,3-triazole analogues
metronidazole
synthesis
Online Access:https://doi.org/10.3762/bjoc.17.154

Internet

https://doi.org/10.3762/bjoc.17.154

Similar Items