Glu-108 in Saccharomyces cerevisiae Rad51 Is Critical for DNA Damage-Induced Nuclear Function

Glu-108 in Saccharomyces cerevisiae Rad51 Is Critical for DNA Damage-Induced Nuclear Function

Rad51-mediated homologous recombination is the major mechanism for repairing DNA double-strand break (DSB) repair in cancer cells. Thus, regulating Rad51 activity could be an attractive target. The sequential assembly and disassembly of Rad51 to the broken DNA ends depend on reversible protein-prote...

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Bibliographic Details
Main Authors: Tanvi Suhane, Vijayalakshmi Bindumadhavan, Nupur Fangaria, Achuthsankar S. Nair, Wahida Tabassum, Poorvaja Muley, Mrinal K. Bhattacharyya, Sunanda Bhattacharyya
Format: Article
Language:English
Published: American Society for Microbiology 2019-03-01
Series:mSphere
Subjects:
DNA repair
Hsp90
homologous recombination
Hsp90-Rad51 interaction
Rad51 recruitment to chromatin
molecular chaperone
Online Access:https://doi.org/10.1128/mSphere.00082-19

Internet

https://doi.org/10.1128/mSphere.00082-19

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