Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models

Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models

The tumoricidal efficiency of human CAR-T cells is generally evaluated using immune-deficient mouse models; however, due to their immune-incompetency and the species-specific reactivity of a target antigen, these models are problematic to imitate CAR-T-induced adverse effects in the clinic. Epitheli...

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Bibliographic Details
Main Authors: Diyuan Qin, Dan Li, Benxia Zhang, Yue Chen, Xuelian Liao, Xiaoyu Li, Peter B. Alexander, Yongsheng Wang, Qi-Jing Li
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
epcam
chimeric antigen receptor
cancer immunotherapy
immuno-oncology
immunocompetent mouse model
toxicities
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1806009

Internet

http://dx.doi.org/10.1080/2162402X.2020.1806009

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