Predictors of insufficient peak amikacin concentration in critically ill patients on extracorporeal membrane oxygenation

Predictors of insufficient peak amikacin concentration in critically ill patients on extracorporeal membrane oxygenation

Abstract Background Amikacin infusion requires targeting a peak serum concentration (Cmax) 8–10 times the minimal inhibitory concentration, corresponding to a Cmax of 60–80 mg/L for the least susceptible bacteria to theoretically prevent therapeutic failure. Because drug pharmacokinetics on extracor...

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Bibliographic Details
Main Authors: Cyril Touchard, Alexandra Aubry, Philippine Eloy, Nicolas Bréchot, Guillaume Lebreton, Guillaume Franchineau, Sebastien Besset, Guillaume Hékimian, Ania Nieszkowska, Pascal Leprince, Charles-Edouard Luyt, Alain Combes, Matthieu Schmidt
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Critical Care
Subjects:
Amikacin
Pharmacokinetics
Acute respiratory distress syndrome
Cardiac failure
Shock
Volume of distribution
Online Access:http://link.springer.com/article/10.1186/s13054-018-2122-x

Internet

http://link.springer.com/article/10.1186/s13054-018-2122-x

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