USP7: Novel Drug Target in Cancer Therapy

USP7: Novel Drug Target in Cancer Therapy

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation. Full activity of USP7 requires the C-terminal Ub-like domains fold back onto the catalytic domain, allowing the remodeling of the active site to a...

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Bibliographic Details
Main Authors: Zhiru Wang, Wenting Kang, Yinghua You, Jingru Pang, Hongmei Ren, Zhenhe Suo, Hongmin Liu, Yichao Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
deubiquitination
USP7
structure
immune
DNA damage
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00427/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00427/full

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