Aberrant fatty acid profile and FFAR4 signaling confer endocrine resistance in breast cancer

Aberrant fatty acid profile and FFAR4 signaling confer endocrine resistance in breast cancer

Abstract Background Evidence suggests that fatty acid receptor FFAR4 plays a tumor-promoting role in adipose tissue-adjacent malignancies, but its clinical relevance remains unexplored. Here, we investigated the clinical significance and underlying mechanisms of FFAR4 in hormone receptor-positive br...

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Bibliographic Details
Main Authors: Xiao Chu, Qi Zhou, Yingchun Xu, Jingting Jiang, Qing Li, Qianjun Zhou, Qiong Wu, Min Jin, Hui Wang, Yuting Gu, Xue Wang, Bei Wang, Songbing He, Xiaozhou He, Changping Wu, Fengchun Zhang, Yanyun Zhang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Fatty acid receptor
FFAR4
Hormone receptor-positive breast cancer
Fatty acids
Gas chromatography-mass spectrometry
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s13046-019-1040-3

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http://link.springer.com/article/10.1186/s13046-019-1040-3

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