Synthetic pathways and processes for effective production of 5-hydroxytryptophan and serotonin from glucose in Escherichia coli

Synthetic pathways and processes for effective production of 5-hydroxytryptophan and serotonin from glucose in Escherichia coli

Abstract Background Tryptophan derivatives such as 5-hydroxytryptophan (5HTP) and serotonin are valuable molecules with pharmaceutical interest. 5HTP is presently mainly obtained by extraction from the plant Griffonia simplicifolia and serotonin is produced by chemical synthesis. A simple biotechnol...

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Bibliographic Details
Main Authors: José-Aníbal Mora-Villalobos, An-Ping Zeng
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Biological Engineering
Subjects:
5-hydroxytryptophan
Serotonin
Protein engineering
Aromatic amino acid hydroxylase
Synthetic pathway
Online Access:http://link.springer.com/article/10.1186/s13036-018-0094-7

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http://link.springer.com/article/10.1186/s13036-018-0094-7

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