SIRT6 is required for normal retinal function.

The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding energy consuming process. Sirtuin 6 (SIRT6), a NAD-dependent deacylase, plays a ke...

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Bibliographic Details
Main Authors: Dafne M Silberman, Kenneth Ross, Pablo H Sande, Shunsuke Kubota, Sridhar Ramaswamy, Rajendra S Apte, Raul Mostoslavsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4045872?pdf=render