Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism.

Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism.

Papillomavirus E2 proteins are predominantly retained in the nuclei of infected cells, but oncogenic (high-risk) HPV-18 and 16 E2 can shuttle between the host nucleus and cytoplasm. We show here that cytoplasmic HPV-18 E2 localizes to mitochondrial membranes, and independent mass spectrometry analys...

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Bibliographic Details
Main Authors: Deborah Lai, Chye Ling Tan, Jayantha Gunaratne, Ling Shih Quek, Wenlong Nei, Françoise Thierry, Sophie Bellanger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3782431?pdf=render

Internet

http://europepmc.org/articles/PMC3782431?pdf=render

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