Effects of annulus defects and implantation of poly(lactic-co-glycolic acid) (PLGA)/fibrin gel scaffolds on nerves ingrowth in a rabbit model of annular injury disc degeneration

Effects of annulus defects and implantation of poly(lactic-co-glycolic acid) (PLGA)/fibrin gel scaffolds on nerves ingrowth in a rabbit model of annular injury disc degeneration

Abstract Background Growth of nerve fibers has been shown to occur in a rabbit model of intravertebral disc degeneration (IVD) induced by needle puncture. As nerve growth may underlie the process of chronic pain in humans affected by disc degeneration, we sought to investigate the factors underlying...

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Bibliographic Details
Main Authors: Long Xin, Weixing Xu, Leijun Yu, Shunwu Fan, Wei Wang, Fang Yu, Zhenbin Wang
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
PLGA scaffold
Fibrin gel
Proteoglycan
Nerve ingrowth
Blood vessels
Annular injury model
Online Access:http://link.springer.com/article/10.1186/s13018-017-0572-5

Internet

http://link.springer.com/article/10.1186/s13018-017-0572-5

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