CCL17 blockade as a therapy for osteoarthritis pain and disease

CCL17 blockade as a therapy for osteoarthritis pain and disease

Abstract Background Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of inflammatory diseases and in osteoarthritis (OA). We identified previously a new GM-CSF→Jmjd3→interferon regulatory factor 4 (IRF4)→chemokine (c-c motif) ligand 17 (CC...

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Bibliographic Details
Main Authors: Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J. Fleetwood, Irmgard Förster, John A. Hamilton, Andrew D. Cook
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
CCL17
Inflammation
Targeting
Animal models
Online Access:http://link.springer.com/article/10.1186/s13075-018-1560-9

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http://link.springer.com/article/10.1186/s13075-018-1560-9

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